Research
Single- incident memory board, associable memory,
and the human genus Hippocampus
Jeffrey J. Gold,3 Ramona O. Hopkins,5,6 and Larry R. Squire1,2,3,4,7
1
Veterans Affairs Medical Center, San Diego, atomic number 20 92161, regular army; 2Department of Psychiatry, University of California, San
Diego, La Jolla, California 92093, USA; 3Department of Neurosciences, University of California, San Diego, La Jolla, California
92093, USA; 4Department of Psychology, University of California, San Diego, La Jolla, California 92093, USA; 5Psychology
Department and Neuroscience Center, Brigham Young University, Provo, do 84602, USA; 6Department of Medicine, Pulmonary
and Critical Care Division, LDS Hospital, Salt Lake City, Utah 84143, USA
We tested recognition memory for items and associations in memory-impaired patients with bilateral lesions thought
to be curb to the hippocampal region. In Experiment 1 (Combined memory test), participants analyse haggling and
then took a memory test in which canvass words, new words, analyse word pairs, and recombined word pairs were
presented in a mixed order. In Experiment 2 (Separated memory test), participants examine single words and then
took a memory test involving canvas word and new words.
In a separate test, they studied word pairs and then took
a memory test involving studied word pairs and recombined word pairs. In both experiments, patients were impaired
at memory for single items as well as memory for associations, suggesting that the hippocampus is important for
both of these memory functions. In Experiment 1, patients appeared to be more impaired at associative memory than
item memory. In Experiment 2, patients were similarly impaired at associative memory and item memory. These
different findings are considered, including the fact that in Experiment 1 the results depended on the fact that
controls produced unexpectedly pathetic false-alarm rates to recombined pairs. We discuss single-item and associative
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